https://www.alessandrabalduini.com/contact daily 0.75 2024-04-08 https://www.alessandrabalduini.com/publications daily 0.75 2024-06-02 https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1613728511060-SJ2UYM2RTP4YD1FT7Q3I/m_bloodjournal_110_2_cover.png Publications https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1613687114680-A152B3V4QOJE38Y3N9H0/m_bloodjournal_118_8_cover.png Publications https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1613833604639-93PUOZZIFJ3CNZLIOK2O/xcover-96-12.jpg.pagespeed.ic.rew3_9Olut.jpg Publications https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1613687115396-KEP8XVZ7ZABVO1MEFHRF/m_bloodjournal_125_14_cover.png Publications https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1613687115907-0XUQCEBOVX4UY67YVGT0/m_bloodjournal_133_12_cover.png Publications https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1658841533466-5K6UOQ6HP4KAEJB9RJ26/TH+121.4_cover.jpg Publications https://www.alessandrabalduini.com/tpo-mimetics daily 0.75 2014-04-28 https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1400068529733-5763NCKC9895FO7RVZOK/romiplostim+sito.jpg TPO mimetics https://www.alessandrabalduini.com/home daily 0.75 2021-04-05 https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384110899637-CJEY0DPZIH9PSW5ZTNXC/megakaryocyte-02.jpg Home - Alessandra Balduini Lab - Megakaryocyte Tubulin staining of a megakaryocyte in adhesion on type I collagen https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384110654376-4V5ZZMBJO2E41OMXUO8U/megakaryocyte.jpg Home - Alessandra Balduini Lab - Megakaryocyte Tubulin and actin staining of a megakaryocyte in adhesion on type I collagen   https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384111299540-QV6QRYQN8MAPXT0KT2XD/proplatelets.jpg Home - Alessandra Balduini Lab - Megakaryocyte extending proplatelets Tubulin staining of a megakaryocyte extending proplatelets https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384111299722-654BZG8PL8M0DVHOGRXQ/megakaryocyte-and-fibronectin.jpg Home - Alessandra Balduini Lab - Megakaryocyte Fibronectin and transglutaminase (factor XIII) colocalization on megakaryocyte membrane https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384112726749-IQREVXDKVGT7Z7NG5BRJ/megakaryocyte-scanning-electron-microscopy.jpg Home - Alessandra Balduini Lab - Megakaryocyte spreading Scanning electron microscopy image of megakaryocyte spread on type I collagen https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384112726773-FJMJY0G6U64TE86IODKV/blood-journal-2007-Proplatelet-regulation-model-by-rho-kinase.jpg Home - Alessandra Balduini Lab - Proplatelet regulation model Proplatelet regulation model by type I collagen and rho kinase. Blood Journal cover story July 2007. https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384112727073-E78EDJZREDTGUDU1A6V3/blood-journal-2011-fibronectin-megakaryocyte.jpg Home - Alessandra Balduini Lab - Model of megakaryocyte interaction within bone marrow environment Novel mechanisms of megakaryocyte interaction with type I collagen. Blood Journal cover story October 2011 https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384113999945-IUUK8QV43UOEKK120MPB/ddr1-expresssion-by-megakaryocyte.jpg Home - Alessandra Balduini Lab - DDR1 expression by megakaryocyte Megakaryocyte expressing new collagen receptor (Discoidin domain receptor 1) https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384113999779-BTDKAZHVZEDL3QERJERP/bone-marrow-model.jpg Home - Alessandra Balduini Lab - Bone marrow model Bioreactor mimicking bone marrow environment for platelet production https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1384114000107-Q8PUQKI0UDF9DV57ACKU/mk-BERNARD-SOULIER-syndrome.jpg Home - Alessandra Balduini Lab - Bernard Soulier syndrome Aberrant proplatelet formation by megakaryocyte derived from patients. https://www.alessandrabalduini.com/autocrine-regulation-of-megakaryocyte-development daily 0.75 2014-04-28 https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1398706199010-N5CF08QSLJZHMWB6ACZ9/calcium-regulation-megakaryocyte-formation.png AUTOCRINE REGULATION OF MEGAKARYOCYTE DEVELOPMENT Figure 2: Di Buduo et al., Heamatologica 2014 https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1398706032502-0DHIQTB60ITE808M00GC/P2Y13-protein-expression.png AUTOCRINE REGULATION OF MEGAKARYOCYTE DEVELOPMENT Figure 1: Analysis of P2Y13 protein expression in human megakaryocytes in culture and in human platelets. CD61+ human megakaryocytes or washed human platelts were lysed and subjected to western blot analysis. A) P2Y13 receptor expression in human megakaryocytes at different days of culture. B) Expression of CD61 and P2Y13 in human megakaryocytes at day 13 of culture and washed human platelets. The membrane were reprobed with anti–b-actin to ensure equal loading (representative of 3 different experiments). https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1398706199010-N5CF08QSLJZHMWB6ACZ9/calcium-regulation-megakaryocyte-formation.png AUTOCRINE REGULATION OF MEGAKARYOCYTE DEVELOPMENT Figure 2: Di Buduo et al., Heamatologica 2014 https://images.squarespace-cdn.com/content/v1/516c369de4b00b44ca2bcdce/1398706032502-0DHIQTB60ITE808M00GC/P2Y13-protein-expression.png AUTOCRINE REGULATION OF MEGAKARYOCYTE DEVELOPMENT Figure 1: Analysis of P2Y13 protein expression in human megakaryocytes in culture and in human platelets. CD61+ human megakaryocytes or washed human platelts were lysed and subjected to western blot analysis. A) P2Y13 receptor expression in human megakaryocytes at different days of culture. B) Expression of CD61 and P2Y13 in human megakaryocytes at day 13 of culture and washed human platelets. 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